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Related Experiment Videos

Immune complexes in cystic fibrosis.

H McFarlane, A Holzel, P Brenchley

    British Medical Journal
    |February 22, 1975
    PubMed
    Summary

    Immune complexes containing immunoglobulins and complement are present in cystic fibrosis (CF) patients. These complexes, found in organs like the lungs, contain antigens such as bovine serum albumin and staphylococcal alpha-haemolysin.

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    Area of Science:

    • Immunology
    • Pulmonology
    • Gastroenterology

    Background:

    • Cystic Fibrosis (CF) is a genetic disorder affecting multiple organs.
    • The role of immune complexes in CF pathogenesis is not fully understood.

    Purpose of the Study:

    • To detect and characterize circulating and tissue-bound immune complexes in cystic fibrosis patients.
    • To identify antigens involved in immune complex formation in CF.

    Main Methods:

    • Detection of immune complexes in serum and sputum.
    • Immune complex elution from organ tissues.
    • Immunoabsorption, autoradiography, and Sephadex G-200 chromatography.
    • Identification of antigens within immune complexes.

    Main Results:

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    • Circulating immune complexes were found in serum and sputum of CF patients.
    • Extensive deposits of immunoglobulins and complement immune complexes were observed in CF organs, particularly the respiratory and gastrointestinal tracts.
    • Significant concentrations of IgG and complement complexes were eluted from CF lungs.
    • Bovine serum albumin and staphylococcal alpha-haemolysin were identified as antigens in the immune complexes.
    • Immune complexes exhibited sedimentation constants of 8S to 11S.

    Conclusions:

    • Immune complexes are a feature of cystic fibrosis, with significant deposition in affected organs.
    • Specific antigens, including environmental ones, are implicated in the formation of these immune complexes.
    • Further research is needed to elucidate the clinical significance of these findings in CF.