Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The imbalanced brain: from normal behavior to schizophrenia.

S Grossberg1

  • 1Department of Cognitive and Neural Systems and Center for Adaptive Systems, Boston University, Boston, Massachusetts 02215, USA.

Biological Psychiatry
|July 21, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The hippocampus and cerebellum in adaptively timed learning, recognition, and movement.

Journal of cognitive neuroscience·2013
Same author

Cortical synchronization and perceptual framing.

Journal of cognitive neuroscience·2013
Same author

A self-organizing neural model of motor equivalent reaching and tool use by a multijoint arm.

Journal of cognitive neuroscience·2013
Same author

Neural Representations for Sensorimotor Control. III. Learning a Body-Centered Representation of a Three-Dimensional Target Position.

Journal of cognitive neuroscience·2013
Same author

Neural networks: introduction to the 1 December 1987 issue of Applied Optics.

Applied optics·2010
Same author

ART 2: self-organization of stable category recognition codes for analog input patterns.

Applied optics·2010

This study models how altered brain signals in neural networks can explain schizophrenia symptoms. Depressed emotional centers in the model lead to negative symptoms, linking brain function to psychiatric conditions.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Computational Psychiatry

Background:

  • Linking brain substrates to mental disorder behaviors is a challenge.
  • Understanding abnormal behaviors as a continuum with normal behaviors is needed.
  • Neural models explain cognitive and emotional processes and their alterations.

Purpose of the Study:

  • To model how emotional brain centers interact with cortical regions.
  • To explain how altered neural signals can generate schizophrenia symptoms.
  • To understand negative symptoms of schizophrenia through neural modeling.

Main Methods:

  • Modeling interactions between the amygdala and prefrontal cortex.
  • Simulating opponent affective processes (e.g., fear, relief) with arousal calibration.

Related Experiment Videos

  • Analyzing how depressed emotional centers affect neural circuits.

    • Main Results:

    • Altered neural models can produce symptoms resembling schizophrenia.
    • Depressed emotional centers in the model lead to negative symptoms.
    • An Inverted-U relationship between arousal and behavior was observed.

    Conclusions:

    • Neural models can bridge the gap between brain mechanisms and psychiatric symptoms.
    • Emotional center dysfunction is a key factor in negative schizophrenia symptoms.
    • This framework supports understanding conscious awareness and psychiatric disorders.