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Related Experiment Videos

Preventing mediastinal shift after pneumonectomy does not abolish physiological compensation.

E Y Wu1, C C Hsia, A S Estrera

  • 1Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235-9034, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|July 25, 2000
PubMed
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Preventing mediastinal shift after pneumonectomy (PNX) impairs lung diffusing capacity (DL(CO)) but allows remaining lung expansion. Compensatory increases in lung tissue volume occur despite limited mediastinal shift.

Area of Science:

  • Pulmonary Physiology
  • Thoracic Surgery
  • Respiratory Medicine

Background:

  • Pneumonectomy (PNX) necessitates compensatory mechanisms in the remaining lung.
  • Mediastinal shift is a common consequence of PNX, potentially influencing lung function.

Purpose of the Study:

  • To investigate the impact of preventing mediastinal shift on compensatory lung responses after pneumonectomy (PNX).

Main Methods:

  • Right pneumonectomy (PNX) in dogs with a prosthesis to either prevent (inflated) or allow (deflated) mediastinal shift.
  • Computerized tomography (CT) for thoracic, lung air, and tissue volumes.
  • Rebreathing technique for lung diffusing capacity for carbon monoxide (DL(CO)) and its components (Dm(CO), Vc).

Main Results:

Keywords:
Non-programmatic

Related Experiment Videos

  • Preventing mediastinal shift (inflated prosthesis) resulted in smaller lung air volume but significant expansion via diaphragmatic displacement.
  • Despite similar rib cage and extravascular tissue volumes, preventing mediastinal shift led to lower DL(CO) and Dm(CO) at equivalent pulmonary blood flow.
  • A delayed mediastinal shift case showed progressive increases in lung volume and DL(CO).

Conclusions:

  • Preventing mediastinal shift post-PNX impairs the recruitment of diffusing capacity.
  • Lung expansion and compensatory increases in extravascular septal tissue volume are not abolished by preventing mediastinal shift.