Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peripheral chemoreflex function in hyperoxia following ventilatory acclimatization to altitude.

M E Pedersen1, P Robach, J P Richalet

  • 1University Laboratory of Physiology, University of Oxford, Parks Road, Oxford OX1 3PT, United Kingdom.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|July 25, 2000
PubMed
Summary

Persistent hyperventilation after high altitude acclimatization is not driven by carotid body activity. Dopamine, a carotid body inhibitor, did not alter ventilation in hyperoxia, refuting this hypothesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Managing Listeria by Cleaning and Disinfection: Experiences from Food Processing Industries and from Manufacturers of Cleaning and Disinfection Agents.

Journal of food protection·2026
Same author

Cloning, expression and functional characterization of prepared bovine, salmon, and cod basic fibroblast growth factor-2.

NPJ science of food·2025
Same author

Hypoventilation training including maximal end-expiratory breath holding improves the ability to repeat high-intensity efforts in elite judo athletes.

Frontiers in physiology·2024
Same author

Early effects of acetazolamide on hemoglobin mass and plasma volume in chronic mountain sickness at 5100 m.

Pulmonology·2023
Same author

Blood pressure and sleep during a 12-month stay at Concordia Station (3233 m), Antarctica.

Pulmonology·2023
Same author

Hypobaric live high-train low does not improve aerobic performance more than live low-train low in cross-country skiers.

Scandinavian journal of medicine & science in sports·2018

Area of Science:

  • Physiology
  • Altitude Medicine
  • Respiratory Control

Background:

  • Ventilatory acclimatization to high altitude (VAH) results in persistent hyperventilation even when the hypoxic stimulus is removed.
  • This sustained hyperventilation may be partly due to altered acid-base status or persistent carotid body (CB) activity.
  • The hypothesis tested is that a component of CB activity develops during VAH that is resistant to suppression by hyperoxia.

Purpose of the Study:

  • To investigate the role of carotid body (CB) activity in persistent hyperventilation after ventilatory acclimatization to high altitude (VAH).
  • To determine if inhibiting the CB with dopamine affects ventilation during hyperoxia following VAH.

Main Methods:

  • Eight volunteers underwent simulated high-altitude ascent in a hypobaric chamber.

Related Experiment Videos

  • Acute hyperoxia exposure was administered at various acclimatization stages.
  • Carotid body inhibition was achieved using dopamine infusion (3 microg.kg(-1).min(-1)) during the latter 10 minutes of hyperoxia.

    • Main Results:

    • Ventilation significantly increased (P < 0.001) and end-tidal PCO(2) significantly decreased (P < 0.001) with VAH.
    • Dopamine infusion during hyperoxia did not progressively affect ventilation or end-tidal PCO(2) in subjects with VAH.
    • These findings indicate that the CB does not generate the persistent hyperventilation observed in hyperoxia post-VAH.

    Conclusions:

    • The carotid body (CB) does not appear to play a significant role in generating persistent hyperventilation after ventilatory acclimatization to high altitude (VAH) when exposed to hyperoxia.
    • The persistent hyperventilation observed in hyperoxia after VAH is likely mediated by factors other than sustained carotid body activity.
    • Further research is needed to elucidate the precise mechanisms underlying persistent hyperventilation post-VAH.