Antifeedant and antifungal activity of chromene compounds isolated from Blepharispermum subsessile

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...

From Water to LandKingdom Plantae first appeared about 470 million years ago as charophyte green algae transitioned from water to land. This land was a relatively uncolonized environment with ample resources. Terrestrial environments also offered more light and carbon dioxide, required by plants to grow and survive.However, the stark differences between land and sea posed a formidable challenge to early colonizing species, prompting many new adaptations that have resulted in the wide variety of...