Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intrinsically long-acting agents compared with long-acting chronoformulations.

P A Meredith1

  • 1Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow G11 6NT, UK. pamlv@clinmed.gla.ac.uk

Blood Pressure Monitoring
|July 25, 2000
PubMed
Summary

Intrinsically long-acting antihypertensive drugs and chronoformulations offer 24-hour blood pressure control. Long-acting drugs are superior for poorly compliant patients, sustaining control even if doses are missed.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The student clinicopathologic conference, a device for the teaching of advanced pathology.

Journal. Association of American Medical Colleges·2014
Same author

Comments on systematic review of clinical- and cost-effectiveness of candesartan and losartan in hypertension and heart failure.

International journal of clinical practice·2011
Same author

Preferential benefits of nifedipine GITS in systolic hypertension and in combination with RAS blockade: further analysis of the 'ACTION' database in patients with angina.

Journal of human hypertension·2010
Same author

Comparison of the efficacy of candesartan and losartan: a meta-analysis of trials in the treatment of hypertension.

Journal of human hypertension·2009
Same author

Lercanidipine: a novel lipophilic dihydropyridine calcium antagonist with long duration of action and high vascular selectivity.

Expert opinion on investigational drugs·2005
Same author

Antihypertensive treatment: full 24 hour control and trough to peak ratio.

Cardiologia (Rome, Italy)·2002

Area of Science:

  • Pharmacology
  • Cardiovascular Medicine

Background:

  • Antihypertensive drugs are crucial for managing blood pressure.
  • Understanding drug delivery mechanisms is key to optimizing treatment efficacy.

Purpose of the Study:

  • To compare the efficacy of intrinsically long-acting antihypertensive drugs versus chronoformulations.
  • To evaluate the impact of patient compliance on blood pressure control.

Main Methods:

  • Comparative analysis of drug pharmacokinetic profiles.
  • Assessment of blood pressure control over a 24-hour period.
  • Evaluation of drug efficacy in relation to patient dosing adherence.

Main Results:

  • Both drug types provide 24-hour blood pressure control.

Related Experiment Videos

  • Intrinsically long-acting drugs offer sustained blood pressure reduction beyond the dosing interval.
  • Long-acting drugs demonstrate superior efficacy in poorly compliant patient populations.

    • Conclusions:

    • Intrinsically long-acting antihypertensives are more effective in patients with poor medication adherence.
    • Chronoformulations and long-acting drugs offer comparable control in highly compliant patients.
    • Drug formulation and patient compliance are critical factors in achieving sustained blood pressure management.