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[Amenorrhoea after oral contraceptives]
Deutsche Medizinische Wochenschrift (1946)
|February 28, 1975
Summary
Post-contraceptive amenorrhea in women often shows impaired responses to clomiphene and LH-RH (luteinizing hormone-releasing hormone) stimulation. Treatment with clomiphene and hCG can provoke ovulation and menstrual bleeding in some cases.
Area of Science:
- Reproductive Endocrinology
- Gynecology
Context:
- Post-contraceptive amenorrhea affects women after oral contraceptive use.
- Investigating hormonal responses in these cases is crucial for understanding reproductive health.
Purpose:
- To assess the hormonal response to clomiphene and Luteinizing Hormone-Releasing Hormone (LH-RH) stimulation in women with amenorrhea post-oral contraceptives.
- To explore potential therapeutic interventions for restoring ovulation and menstruation.
Summary:
- Eleven women with amenorrhea post-oral contraceptives underwent stimulation tests.
- Most showed impaired responses to clomiphene and LH-RH.
- Bleeding was provoked by continued clomiphene, and ovulation occurred with added hCG in some patients.
Impact:
- Suggests potential treatment pathways for post-contraceptive amenorrhea.
- Highlights the potential role of psychosomatic factors in the condition's development.
- Informs clinical management strategies for reproductive disorders.
Keywords:
AmenorrheaBiologyClinical ResearchClomiphene--therapeutic useContraceptionContraceptive Agents, Female--therapeutic useContraceptive Agents, Progestin--therapeutic useContraceptive Agents--therapeutic useContraceptive Methods--side effectsDiseasesEndocrine SystemFamily PlanningFertility AgentsGonadotropinsGonadotropins, Chorionic--therapeutic useHormonesLuteinizing HormoneMenstruation DisordersOral Contraceptives, Combined--side effectsOral Contraceptives--side effectsPhysiologyPituitary Hormone Releasing Hormones--therapeutic useReproductive Control AgentsResearch Methodology