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Related Experiment Video

Updated: Jul 16, 2026

Imaging Intracellular Ca2+ Signals in Striatal Astrocytes from Adult Mice Using Genetically-encoded Calcium Indicators

Imaging Intracellular Ca²⁺ Signals in Striatal Astrocytes from Adult Mice Using Genetically-encoded Calcium Indicators

Published on: November 19, 2014

Expression of lysophosphatidic acid receptor in rat astrocytes: mitogenic effect and expression of neurotrophic

S Tabuchi¹, K Kume, M Aihara

¹Division of Neurosurgery, Institute of Neurological Sciences, Tottori University School of Medicine, Yonago, Japan.

Neurochemical Research

|July 25, 2000

Summary

Lysophosphatidic acid (LPA) receptors are primarily found in rat astrocytes. LPA signaling in astrocytes influences gene expression and cell growth, suggesting roles in brain development and repair.

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Monitoring Astrocyte Reactivity and Proliferation in Vitro Under Ischemic-Like Conditions

Monitoring Astrocyte Reactivity and Proliferation in Vitro Under Ischemic-Like Conditions

Published on: October 21, 2017

Area of Science:

Neuroscience
Cell Biology
Biochemistry

Background:

Lysophosphatidic acid (LPA) is a bioactive phospholipid mediator.
The specific cell types expressing LPA receptors in the brain remain largely unidentified.

Purpose of the Study:

To identify brain cells expressing functional LPA receptors.
To investigate the biological roles of LPA in these identified cells.

Main Methods:

Calcium (Ca2+) imaging to detect LPA-induced responses.
Northern blot analysis for gene expression.
Pertussis-toxin sensitivity assays for G-protein coupling.

Main Results:

LPA receptors are predominantly expressed in rat astrocytes.
LPA triggers a mitogenic response and immediate early gene expression in astrocytes.
LPA stimulates the expression of key cytokines, including nerve growth factor and interleukins (IL-1beta, IL-3, IL-6).

Conclusions:

Astrocytes are the primary targets of LPA in the brain.
LPA signaling in astrocytes may be crucial for neuronal development, gliosis, and brain wound healing.