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Drug-resistant Salmonella enterica serotype paratyphi A in India

D S Chandel1, R Chaudhry, B Dhawan

  • 1All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.

Emerging Infectious Diseases
|July 25, 2000
PubMed

Insights

Drug-resistant Salmonella Paratyphi A is increasingly causing enteric fever in India. Since 1998, New Delhi has seen a rise in infections resistant to multiple antibiotics, including chloramphenicol and cotrimoxazole.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Enteric fever, caused by Salmonella enterica serotype Paratyphi A, has shown a rising incidence in India since 1996.
  • A significant increase in drug-resistant S. Paratyphi A infections was observed in New Delhi starting in 1998.

Purpose of the Study:

  • To document the increasing incidence of enteric fever in India.
  • To investigate the emergence and antimicrobial resistance patterns of Salmonella Paratyphi A in New Delhi.

Main Methods:

  • Surveillance of enteric fever cases.
  • Bacteriological isolation and antimicrobial susceptibility testing of Salmonella Paratyphi A isolates.

Main Results:

  • The incidence of enteric fever due to Salmonella Paratyphi A has been increasing in India.
  • In the first half of 1999, 32% of S. Paratyphi A isolates in New Delhi were resistant to chloramphenicol and cotrimoxazole.
  • An additional 13% of isolates exhibited resistance to more than two antibiotics.

Conclusions:

  • Emergence of multidrug-resistant Salmonella Paratyphi A poses a significant public health challenge in India.
  • Antimicrobial resistance patterns require continuous monitoring to guide treatment strategies for enteric fever.

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