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Updated: Oct 15, 2026

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
Characterization of a novel respiratory syncytial virus-specific human cytotoxic T-lymphocyte epitope
P J Goulder1, F Lechner, P Klenerman
1Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA. goulder@helix.mgh.harvard.edu
Abstract:
Respiratory syncytial virus (RSV) infection is a major cause of morbidity in childhood worldwide. The first human RSV-specific cytotoxic T-lymphocyte epitope to be defined is described. This HLA B7-restricted epitope in nucleoprotein (NP) was detectable in four healthy, B7-positive adult subjects using B7-RSV-NP tetrameric complexes to stain CD8(+) T cells.
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