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Updated: Jul 27, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
Published on: June 15, 2017
Proteolysis and developmental signal transduction
1Department of Genetics, Stellar-Chance Laboratories, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
Abstract:
Regulated proteolysis is a critical feature of many intercellular signalling pathways that control cell-fate specification and tissue patterning during metazoan development. The roles of proteolysis in three different pathways, the Toll, Hedgehog, and Notch pathways, are described to illustrate the importance of specific protein cleavages in both extracellular ligand-receptor interactions and intracellular signal transduction. An emerging principle is the use of proteolysis to control the maturation and activation of receptors, to limit the spatial diffusion of their ligands, and to modulate the subcellular localization or transcriptional activity of DNA-binding factors in response to receptor-ligand interactions at the cell surface.
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