Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in canine peripheral nerves during experimental callus distraction.

B Fink1, E Neuen-Jacob, J Lehmann

  • 1Orthopaedic Department, University-Hospital Hamburg-Eppendorf, Germany.

Clinical Orthopaedics and Related Research
|July 25, 2000
PubMed
Summary

Callus distraction for leg lengthening caused minor nerve fiber damage, with signs of regeneration and some nerve fiber growth observed in beagles. These findings suggest moderate degenerative changes followed by repair and near-complete recovery.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence that the Aso-3 caldera-forming eruption (southwest Japan) marks the termination of Marine Isotope Stage (MIS) 6.

Quaternary science reviews·2026
Same author

Genicular Artery Embolization Using Resorbable Gelatin Microspheres for Refractory Knee Pain: Technique, Safety and Clinical Outcome.

Cardiovascular and interventional radiology·2025
Same author

Digit ratio (2D:4D) and its relationship to foetal and maternal sex steroids: A mini-review.

Early human development·2023
Same author

The effects of sex, nation, ethnicity, age and self-reported pubertal development on participant-measured right-left 2D:4D (Dr-l) in the BBC internet study.

Journal of biosocial science·2022
Same author

Digit ratio (2D:4D) and body mass index in the BBC Internet Study: prenatal sex steroids and a Trivers-Willard effect on body composition.

Journal of biosocial science·2021
Same author

Parental income inequality and children's digit ratio (2D:4D): a 'Trivers-Willard' effect on prenatal androgenization?

Journal of biosocial science·2021

Area of Science:

  • Orthopedics
  • Regenerative Medicine
  • Neuroscience

Background:

  • Leg lengthening procedures, such as callus distraction, are crucial in orthopedic surgery.
  • Understanding the impact of these procedures on peripheral nerves is essential for patient outcomes.

Purpose of the Study:

  • To investigate the effects of tibial lengthening via callus distraction on the tibial and peroneal nerves in beagles.
  • To analyze nerve fiber alterations, including degeneration and regeneration, following the distraction osteogenesis process.

Main Methods:

  • Tibial lengthening was performed on beagles using a ring fixator and callus distraction technique.
  • Nerves were harvested at different time points (immediately after distraction and after consolidation) for morphometric and electron microscopic analysis.

Related Experiment Videos

  • A control group with tibial osteotomy and external fixation without distraction was included for comparison.

    • Main Results:

    • Minor alterations in myelinated nerve fibers were observed, including remyelination and single axon degeneration.
    • Electron microscopy revealed late Wallerian degeneration and axonal regeneration in nonmyelinated axons.
    • Morphometric analysis showed increased fiber density and reduced axon/fiber diameter during consolidation, with tibial nerve changes resolving post-consolidation.

    Conclusions:

    • Callus distraction induces moderate, transient degenerative changes in peripheral nerves.
    • The nerves exhibit repair mechanisms, leading to near-complete recovery and some evidence of nerve fiber growth.
    • These findings support the safety and regenerative potential of callus distraction in limb lengthening procedures.