Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Hypercoagulation in patients with nephrotic syndrome].

Z Zdrojewski1, A Raszeja-Specht, A Skibowska

  • 1Kliniki Chorób Nerek Instytutu Chorób Wewnetrznych, Gdańsku.

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|January 1, 1997
PubMed
Summary

Platelet changes in nephrotic syndrome (NS) contribute to hypercoagulation. Altered platelet morphology and increased aggregation suggest a key role in thrombotic complications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical characteristics of Polish patients with ANCA-associated vasculitides-retrospective analysis of POLVAS registry.

Clinical rheumatology·2019
Same author

Evaluation of Pretransplant Donor-Specific Alloantibodies With Different Crossmatch Techniques.

Transplantation proceedings·2018
Same author

Management of Renin-Angiotensin-Aldosterone System Blockade in Kidney Transplant Recipients.

Transplantation proceedings·2018
Same author

Solid Organ Cancer and Melanoma in Kidney Transplant Recipients: TumorTx Base Preliminary Results.

Transplantation proceedings·2018
Same author

Paired Analysis of Outcomes After Kidney Transplantation in Peritoneal and Hemodialysis Patients.

Transplantation proceedings·2018
Same author

Improvement of Blood Pressure Control in Renal Transplant Recipients-Retrospective Longitudinal Study.

Transplantation proceedings·2018

Area of Science:

  • Nephrology
  • Hematology
  • Pathophysiology

Context:

  • Nephrotic syndrome (NS) is associated with hypercoagulation and thrombotic risks.
  • The precise mechanisms underlying these complications remain unclear.
  • Platelets are implicated in hypercoagulation, but their specific role in NS requires further elucidation.

Purpose:

  • To investigate the role of platelets in the hypercoagulation observed in nephrotic syndrome patients.
  • To analyze platelet count, mean platelet volume (MPV), and platelet distribution width (PLT Mode) in NS.
  • To assess platelet aggregation patterns in NS patients.

Summary:

  • Studies in 15 NS patients and 15 healthy controls revealed decreased antithrombin III (AT III) and a non-significant increase in fibrinogen.

Related Experiment Videos

  • NS patients exhibited decreased MPV and PLT Mode, alongside increased spontaneous platelet aggregation and heightened sensitivity to aggregating agents.
  • These findings suggest that multifactorial mechanisms contribute to hypercoagulation in NS, with platelet morphology and function playing a significant role.

    • Impact:

    • Highlights the multifactorial nature of hypercoagulation in nephrotic syndrome.
    • Identifies alterations in platelet morphology and function as potential contributors to thrombotic events in NS.
    • Provides insights for potential therapeutic strategies targeting platelet activity in NS management.