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Published on: February 5, 2014
Color and graphic display (CGD): programs for multiple sequence alignment analysis in spreadsheet software
1CNRS UPRES-A 6026 Université de Rennes 1, France. cdelam@univ-rennes1.fr
Biotechniques
|July 25, 2000
Summary
Color and Graphic Display (CGD) is a user-friendly tool that runs in Microsoft Excel for analyzing protein and DNA sequence alignments. It helps scientists easily identify important residues and organize sequence families.
Area of Science:
- Bioinformatics
- Computational Biology
- Molecular Biology
Background:
- Multiple sequence alignment interpretation is crucial for predicting protein domains and organizing sequence families.
- Bench scientists require accessible and efficient computational tools for sequence analysis.
Purpose of the Study:
- To introduce Color and Graphic Display (CGD), a novel software module for analyzing multiple sequence alignments.
- To demonstrate CGD's utility in highlighting functionally important residues within protein families.
Main Methods:
- CGD is presented as a set of modules integrated within Microsoft Excel.
- The software facilitates the coloring and graphical analysis of multiple sequence alignments.
- Its application is exemplified using a water channel protein family.
Main Results:
- CGD provides a user-friendly interface for complex sequence alignment analysis.
- The program effectively highlights key residues, aiding in functional and structural domain prediction.
- CGD demonstrates compatibility with both protein and DNA sequence data.
Conclusions:
- CGD offers a valuable and accessible tool for researchers analyzing multiple sequence alignments.
- The software enhances the interpretation of sequence data, supporting domain prediction and family organization.
- Its versatility extends to both protein and DNA sequence analysis, broadening its applicability.
