Preparation and antimicrobial activity of micacocidin
Related Experiment Video
Updated: Oct 15, 2026

Production and Testing of Antimicrobial Peptides and Their Mimics
Published on: April 10, 2026
S Kobayashi1, Y Ikenishi, Y Takinami
1Aburahi Laboratories, Shionogi & Co Ltd, Koka, Shiga, Japan.
Abstract:
Micacocidin (3), a Zn-free derivative of micacocidin A (1), was prepared to evaluate its antimicrobial activity in comparison with 1 and to obtain a starting material for chemical modification of 1. The structure of 3, quite unlike those of any previously known antimicrobial agents, was elucidated by 1-D and 2-D homonuclear and heteronuclear NMR and mass spectroscopy. Micacocidin (3) thus prepared exhibited weak or no antibacterial activity except against Mycoplasma species, i.e. 3 showed stronger activity than 1. It is noteworthy that 3 displayed high activity against fungi such as Candida, Aspergillus and Trichophyton species.
Related Concept Videos
Microbial Corrosion
Antimicrobial Effectiveness
Clinical Significance of Antibiotic Resistance
Antimicrobial Proteins
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Antifungal Agents

