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Related Experiment Videos

Nicotine replacement therapy for smoking cessation.

C Silagy1, D Mant, G Fowler

  • 1Monash Institute of Public Health and Health Service Research, Monash Medical Centre, Locked Bag 29, Clayton, Victoria, Australia, 3168. chris.silagy@med.monash.edu.au

The Cochrane Database of Systematic Reviews
|July 25, 2000
PubMed
Summary
This summary is machine-generated.

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Nicotine replacement therapy (NRT) effectively increases smoking cessation rates by 1.5 to 2 fold, with various forms like gum and patches showing similar efficacy. Bupropion may offer greater effectiveness, warranting further research.

Area of Science:

  • Pharmacology
  • Addiction Medicine
  • Public Health

Background:

  • Nicotine replacement therapy (NRT) aims to reduce withdrawal symptoms during smoking cessation by substituting nicotine from cigarettes.
  • NRT aids smokers in resisting the urge to smoke, supporting cessation efforts.

Purpose of the Study:

  • To evaluate the effectiveness of various NRT forms (gum, patches, nasal spray, inhalers, tablets) for smoking abstinence.
  • To assess if clinical setting, NRT dosage/form, or support intensity influences NRT effectiveness.
  • To compare combination NRT efficacy and NRT effectiveness against other pharmacotherapies.

Main Methods:

  • A systematic review of randomized controlled trials comparing NRT to placebo or no treatment.
  • Searched the Cochrane Tobacco Addiction Group trials register (April 2000).

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  • Included trials with follow-up of at least six months and reported cessation rates; meta-analysis used a fixed effects model.

    • Main Results:

    • NRT demonstrated an overall odds ratio of 1.71 for abstinence compared to control.
    • Specific NRT forms showed varying odds ratios: gum (1.63), patches (1.73), nasal spray (2.27), inhalers (2.08), and tablets (1.73).
    • Bupropion showed higher efficacy than NRT in one comparative study.

    Conclusions:

    • All commercially available NRT forms are effective in promoting smoking cessation, increasing quit rates approximately 1.5 to 2 fold.
    • NRT effectiveness is largely independent of support intensity, though brief advice is recommended.
    • Bupropion shows promise as a potentially more effective smoking cessation aid than NRT.