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Psychological therapies for sickle cell disease and pain
1Brent Sickle Cell and Thalassaemia Centre, Central Middlesex Hospital, Park Royal, London, UK, NW10 7NS. kanie@sghms.ac.uk
Background:
Sickle cell disease comprises of a group of genetic blood disorders, and occurs when the sickle cell haemoglobin gene is inherited from both parents. The effects of the condition are: varying degrees of anaemia which if severe reduce the capacity for mobility; predisposition to obstruction of small blood capillaries causing pain in muscle and bone known as "crises"; damage to major organs such as the spleen, liver, kidneys, and lungs; and increased vulnerability to severe infections. There are both medical and non-medical complications, and treatment is usually symptomatic and palliative in nature. Psychological intervention for individuals with sickle cell disease seems viable in complementing current medical treatment, and studies examining their efficacy appear to have also yielded encouraging results.
Objectives:
To examine the evidence that in patients with sickle cell disease, psychological treatment improves the ability to cope with the condition.
Search Strategy:
The Cochrane Cystic Fibrosis and Genetic Disorders Group specialist trials register which comprises references from comprehensive electronic database searches, handsearching relevant journals and handsearching abstract books of conference proceedings. Also, searches on the Internet were performed.
Selection Criteria:
All randomised or quasi-randomised controlled trials comparing the use of psychological intervention to no (psychological) intervention in patients with sickle cell disease.
Data Collection And Analysis:
The following outcomes were assessed: pain, mood, coping, health service utilisation, general health, quality of life, and life satisfaction.
Main Results:
Four trials which reported results were all found to be unsuitable for inclusion at the present time, owing to incomplete data in the published papers.
Reviewer'S Conclusions:
Psychological approaches are commonly used in an attempt to improve coping ability in patients with sickle cell disease. No conclusions can be made about the use of specific psychological therapies in sickle cell disease from the information currently available. This systematic review has clearly identified the need for well designed, adequately-powered, multicentre, RCTs assessing the effectiveness of specific interventions in sickle cell disease.