Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Steroids for treating tuberculous meningitis.

K Prasad1, J Volmink, G R Menon

  • 1Neurology, All India Institute of Medical Sciences, Ansarinagar, New Delhi, Delhi, India, 110029. kprasad@medinst.ernet.in

The Cochrane Database of Systematic Reviews
|July 25, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Revisiting the Intratemporal Course of the Facial Nerve.

Cureus·2024
Same author

Investigating Sources of Variability and Error in Simulations of Carbon Dioxide in an Urban Region.

Atmospheric environment (Oxford, England : 1994)·2024
Same author

Radioactive seed localization is a safe and effective tool for breast cancer surgery: an evaluation of over 25,000 cases.

Journal of radiological protection : official journal of the Society for Radiological Protection·2024
Same author

Eco-safe composite edible coating of hydrocolloids with papaya leaf extract improves postharvest quality and shelf life of papaya fruit under ambient storage.

Journal of food science·2024
Same author

Characterization of bioactive and fruit quality compounds of promising mango genotypes grown in Himalayan plain region.

PeerJ·2023
Same author

Impact of shield location on staff and caregiver dose rates for I-131 radiopharmaceutical therapy patients.

Journal of radiological protection : official journal of the Society for Radiological Protection·2023

Corticosteroids may reduce death and disability in tuberculous meningitis (TBM) patients. However, evidence is limited, especially for those with HIV, necessitating larger trials.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Clinical Trials

Background:

  • Corticosteroid use in tuberculous meningitis (TBM) is controversial, with unclear benefits and risks, particularly in HIV-infected individuals.
  • Existing evidence on corticosteroids for TBM is limited and debated.

Purpose of the Study:

  • To evaluate the impact of steroid therapy on mortality and disability outcomes in patients diagnosed with TBM.
  • To synthesize evidence from randomized controlled trials regarding corticosteroid efficacy in TBM treatment.

Main Methods:

  • Systematic electronic search of major medical databases (MEDLINE, Cochrane Registers) for relevant randomized controlled trials (RCTs).
  • Inclusion criteria focused on RCTs involving steroids in patients receiving anti-tuberculosis treatment for TBM.

Related Experiment Videos

  • Data extraction and quality assessment performed by two independent reviewers.

    • Main Results:

    • Six trials involving 595 patients were analyzed; allocation concealment was poor in all studies.
    • Corticosteroids were associated with a significant reduction in mortality (RR 0.79; 95% CI 0.65 to 0.97).
    • A notable decrease in the combined outcome of death and severe residual disability was observed (RR 0.58, 95% CI 0.38 to 0.88), particularly in children.

    Conclusions:

    • Adjunctive corticosteroids may offer benefits for patients with TBM, potentially reducing mortality and disability.
    • The positive findings may be influenced by study limitations, including small sample sizes, poor allocation concealment, and potential publication bias.
    • Further large-scale, placebo-controlled trials are essential, especially including HIV-positive patients, to definitively establish the role of steroids in TBM management.