Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Major histocompatibility complex phenotypes influence serum testosterone concentration.

B Larsen1, C A King, M Simms

  • 1Faculty of Medicine, Memorial University of Newfoundland, St John's, Newfoundland, Canada.

Rheumatology (Oxford, England)
|July 26, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

sendigR: an R package to leverage the value of CDISC SEND datasets for cross-study analysis.

Frontiers in toxicology·2024
Same author

Do measures of social support and social distress share general factors associated with suicidal ideation and attempts?

Suicide & life-threatening behavior·2024
Same author

Predicting short-term suicidal thoughts in adolescents using machine learning: developing decision tools to identify daily level risk after hospitalization.

Psychological medicine·2021
Same author

A hepatitis C elimination model in healthcare for the homeless organization: A novel reflexive laboratory algorithm and equity assessment.

The International journal on drug policy·2021
Same author

Short-term associations between nonsuicidal and suicidal thoughts and behaviors: A daily diary study with high-risk adolescents.

Journal of affective disorders·2021
Same author

A comparison of self-reported risk and protective factors and the death implicit association test in the prediction of future suicide attempts in adolescent emergency department patients.

Psychological medicine·2021
Same journal

Disease activity and anti-topoisomerase I antibody positivity are associated with elevated serum B cell-activating factor levels and a B cell subset-wide reduction of BAFF receptor expression in systemic sclerosis.

Rheumatology (Oxford, England)·2026
Same journal

Progression from oligoarticular to polyarticular psoriatic arthritis and apremilast as a disease modifier: novel insights from FOREMOST.

Rheumatology (Oxford, England)·2026
Same journal

Personalized, physiotherapist-guided exercise programs in juvenile ıdiopathic arthritis: home-based vs. ımmersive virtual reality (JiaFitXR).

Rheumatology (Oxford, England)·2026
Same journal

Prolonged B-cell depletion after single-dose obinutuzumab in antisynthetase syndrome following rituximab intolerance.

Rheumatology (Oxford, England)·2026
Same journal

Radiographic Sacroiliitis Progression in Psoriatic Arthritis.

Rheumatology (Oxford, England)·2026
Same journal

Stability and prognostic value of B-cell markers in primary Sjögren's syndrome: results from the French ASSESS cohort.

Rheumatology (Oxford, England)·2026
See all related articles

The human leukocyte antigen (HLA) phenotype HLA-DR4,7 is more common in male rheumatoid arthritis (RA) patients. A man's major histocompatibility complex (MHC) type may influence testosterone levels, but its link to RA pathogenesis is unclear.

Area of Science:

  • Immunogenetics
  • Rheumatology
  • Endocrinology

Background:

  • The human leukocyte antigen (HLA) phenotype HLA-DR4,7 is observed more frequently in male patients with rheumatoid arthritis (RA) compared to female patients.
  • A potential link between low serum testosterone (Te) levels and RA in males has been hypothesized.
  • This study investigates the association between HLA alleles and serum Te concentration in healthy males to understand this potential relationship.

Purpose of the Study:

  • To confirm the higher frequency of HLA-DR4,7 in male RA patients.
  • To test if DR7 is associated with low normal serum Te levels in healthy males.
  • To characterize the association between specific HLA alleles and serum Te concentration in healthy males.

Main Methods:

  • HLA-DR typing was performed on 82 male RA patients from Newfoundland, combined with previous data for a total of 373 RA patients.

Related Experiment Videos

  • 94 healthy Newfoundland males were typed for HLA, TNFa microsatellite marker, and complement factor B (BF).
  • An additional 38 males were included, with some selected based on HLA-B type.

    • Main Results:

    • The higher frequency of HLA-DR4,7 in male RA patients was confirmed (P<0.01).
    • Contrary to expectations, DR7 was associated with higher than average Te levels, as were B5, B27, DR1, TNFa7, and BF F positivity.
    • Low Te concentrations were associated with B15, DR2, DR5, TNFa5, and BF F negativity. No association was found between HLA alleles and low Te levels in early-onset RA patients.

    Conclusions:

    • A man's major histocompatibility complex (MHC) phenotype may influence his serum testosterone concentration.
    • The precise relationship between MHC phenotype, testosterone levels, and the pathogenesis of rheumatoid arthritis remains speculative and requires further investigation.