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Related Experiment Videos

Tryptophan hydroxylase polymorphisms in suicide victims.

P J Bennett1, W M McMahon, J Watabe

  • 1Department of Psychiatry, School of Medicine, University of Utah, Salt Lake City 84132, USA. Pamela.Bennett@hsc.utah.edu

Psychiatric Genetics
|July 26, 2000
PubMed
Summary

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Genetic factors, specifically Tryptophan hydroxylase (TPH) gene polymorphisms, were investigated for their link to suicide risk. This study found no association between specific TPH gene variants and suicide in Caucasian males.

Area of Science:

  • Genetics
  • Neuroscience
  • Psychiatry

Background:

  • Suicide risk is influenced by both environmental and genetic factors.
  • The serotonergic system plays a role in depression, impulsivity, and suicidality.
  • Tryptophan hydroxylase (TPH) is key in serotonin synthesis and its gene has been linked to suicide.

Purpose of the Study:

  • To investigate the association between TPH gene polymorphisms (A218C and A779C) and suicide risk.
  • To analyze these genetic associations in a sample of deceased Caucasian males from the Utah Youth Suicide Study.

Main Methods:

  • DNA samples from 47 deceased Caucasian males were analyzed.
  • A 918 base pair fragment of the TPH gene was amplified.
  • The A218C polymorphism was analyzed using restriction fragment length polymorphism (RFLP).

Related Experiment Videos

  • The A779C polymorphism was analyzed using DNA sequencing.

    • Main Results:

    • Neither the A218C nor the A779C polymorphism in the TPH gene was associated with suicide in the study population.
    • Stratification by age (10-21 and 22-31 years) or selection for violent suicides did not alter these findings.

    Conclusions:

    • The studied TPH gene polymorphisms do not appear to be directly associated with suicide risk in this Caucasian male cohort.
    • The complex nature of suicide suggests multiple interacting biological and social factors contribute to its etiology.