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Related Experiment Videos

Search for association between suicide attempt and serotonergic polymorphisms.

T Geijer1, A Frisch, M L Persson

  • 1National and Stockholm County Council Centre for Suicide Research and Prevention of Mental Ill-health, National Institute for Psychosocial Factors and Health, Sweden.

Psychiatric Genetics
|July 26, 2000
PubMed
Summary

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Genetic variations in serotonin pathways are linked to suicidal behavior. This study found no direct link for specific gene polymorphisms, but a combined analysis suggests a significant association with tryptophan hydroxylase and suicide attempts.

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Serotonergic neurotransmission plays a role in suicidal behavior.
  • Genetic polymorphisms in key serotonin-related genes are potential risk factors for suicide attempts.

Purpose of the Study:

  • To investigate the association between polymorphisms in tryptophan hydroxylase (TPH), serotonin receptor 2A (5-HTR2A), and serotonin transporter (5-HTT) genes and suicide attempts.
  • To examine these associations across different psychiatric diagnostic categories.

Main Methods:

  • Case-control study comparing suicide attempters (n=165) with healthy controls (n=99).
  • Genotyping for polymorphisms in TPH, 5-HTR2A, and 5-HTT genes.
  • Statistical analysis, including subgroup analysis by diagnosis and meta-analysis with existing literature.

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Main Results:

  • No significant differences in TPH, 5-HTR2A, or 5-HTT polymorphisms were found between suicide attempters and controls.
  • Subgroup analyses across unipolar disorder, adjustment disorder, substance use disorder, and personality disorder (cluster B) also showed no significant differences.
  • A significant allelic association between tryptophan hydroxylase and suicide attempt emerged after pooling data with literature (P = 0.001).

Conclusions:

  • The investigated polymorphisms in TPH, 5-HTR2A, and 5-HTT genes do not appear to be major determinants of suicide attempts in the studied sample.
  • A potential association between tryptophan hydroxylase polymorphism and suicide attempt risk is suggested, particularly when considering pooled data and specific phenotypes.