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Cytotoxic neolignans from the stem wood of Machilus obovatifolia

I L Tsai1, J H Chen, C Y Duh

  • 1Graduate Institute of Natural Products, Kaohsiung Medical University, Taiwan, R.O.C. ialits@cc.kmu.edu.tw

Planta Medica
|July 26, 2000
PubMed

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Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...