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Bioactive compounds from Celaenodendron mexicanum.

M R Camacho1, R Mata, P Castaneda

  • 1Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London, UK. mcamacho@ulsop.ac.uk

Planta Medica
|July 26, 2000
PubMed
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Celaenodendron mexicanum leaf extract yielded novel triterpenes and biflavonoids. Epi-oleanolic acid showed significant brine shrimp lethality, while 3-oxotirucalla-7,24Z-dien-26-oic acid and epi-oleanolic acid exhibited potent antiprotozoal activity.

Area of Science:

  • Natural Product Chemistry
  • Pharmacognosy
  • Medicinal Chemistry

Background:

  • Celaenodendron mexicanum is a plant species with potential medicinal properties.
  • Phytochemical investigation is crucial for discovering new bioactive compounds.

Purpose of the Study:

  • To isolate and characterize bioactive compounds from Celaenodendron mexicanum leaves.
  • To evaluate the antiprotozoal and cytotoxic activities of isolated compounds.

Main Methods:

  • Bioactivity-directed fractionation using brine shrimp lethality assay.
  • Isolation and purification via chromatographic techniques.
  • In vitro testing for antiprotozoal and cytotoxic effects.

Main Results:

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  • Three carboxylic acid triterpenes (including a new tirucalla-type triterpene) and three biflavonoids were isolated.
  • Epi-oleanolic acid demonstrated the highest brine shrimp lethality (LC50 = 23.3 µM).
  • 3-Oxotirucalla-7,24Z-dien-26-oic acid and epi-oleanolic acid showed significant activity against Leishmania donovani.
  • 3-Oxotirucalla-7,24Z-dien-26-oic acid was active against Trypanosoma brucei brucei.

    • Conclusions:

    • Celaenodendron mexicanum leaves contain bioactive triterpenes with potential antiprotozoal properties.
    • The isolated compounds, particularly 3-oxotirucalla-7,24Z-dien-26-oic acid and epi-oleanolic acid, warrant further investigation for drug development.