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Blood volume.

R R Wright, M Tono, M Pollycove

    Seminars in Nuclear Medicine
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Accurate blood volume determination is crucial for diagnosis and therapy. This study presents a refined method addressing historical inaccuracies in plasma volume and red cell volume measurements.

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    Area of Science:

    • Medical Diagnostics
    • Physiology

    Background:

    • Diagnostic use of blood volume determinations has declined due to inaccurate results and interpretation.
    • Current methods use 125I-labeled albumin for plasma volume and 51Cr-labeled red blood cells for red cell volume.

    Purpose of the Study:

    • To present a rapid, routine method for accurate blood volume determination.
    • To address historical inaccuracies in plasma volume and red cell volume measurements.
    • To highlight the diagnostic and therapeutic utility of precise blood volume assessments.

    Main Methods:

    • Abandoning the mean body hematocrit:venous hematocrit ratio for independent volume measurements.
    • Ensuring complete mixing and equilibration before collecting patient samples.
    • Utilizing back-extrapolation techniques for plasma albumin and red cell concentrations.

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  • Normalizing volumes by adjusting patient weight to lean tissue mass.

    • Main Results:

    • A rapid, routine method fulfilling four key requirements for accurate blood volume determination is presented.
    • The method addresses issues of incomplete mixing, albumin/red cell loss, and inappropriate normalization.
    • Newly developed techniques like neutron activation analysis and fluorescent excitation analysis are mentioned.

    Conclusions:

    • Correct normalization of accurate blood volume measurements can significantly aid medical diagnosis and therapy.
    • The presented method offers a valuable service to the medical community by improving diagnostic accuracy.
    • Accurate blood volume determinations remain vital in various surgical and medical conditions.