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Related Experiment Videos

Moving beyond the immune self?

A I Tauber1

  • 1Center for Philosophy and History of Science, Boston University, 745 Commonwealth Avenue, Boston, MA 02215, USA. ait@bu.edu

Seminars in Immunology
|July 27, 2000
PubMed
Summary
This summary is machine-generated.

The concept of immune self is challenged, moving beyond simple self/nonself discrimination. New models emphasize context-dependent immune responses integrated within the whole organism, with Jerne's theory gaining traction.

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Area of Science:

  • Immunology
  • Theoretical Biology

Background:

  • The traditional concept of immune self, based on strict self/nonself discrimination, is being challenged.
  • Transplantation biology and autoimmunity reveal complexities that defy a simple dichotomy.
  • Immune responses are increasingly viewed as context-dependent rather than solely based on foreignness.