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Frequency of anxiety disorders in psychiatric outpatients with major depressive disorder
M Zimmerman1, W McDermut, J I Mattia
1Department fo Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence 02905, USA. MZimmerman@Lifespan.org
Objective:
The authors determined the frequency of anxiety disorders in a large group of depressed outpatients seeking treatment.
Method:
The Structured Clinical Interview for DSM-IV was administered to 373 depressed outpatients.
Results:
More than one-half of the patients met the full criteria for a current anxiety disorder, and more than one-half of the patients with an anxiety disorder had more than one. When partial remissions and anxiety disorder diagnoses classified as "not otherwise specified" were included, two-thirds of the patients had a current anxiety disorder and three-quarters had a lifetime history of an anxiety disorder.
Conclusions:
The majority of patients with a principal diagnosis of unipolar major depressive disorder have a comorbid anxiety disorder. Because antidepressant medications have differential efficacies for anxiety disorders, knowledge of the presence of a comorbid anxiety disorder in a depressed patient may have treatment implications.