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Myocardial dysfunction associated with proinflammatory cytokines after esophageal resection
K Nakanishi1, S Takeda, K Terajima
1Departments of Anesthesiology, Nippon Medical School, Tokyo, Japan.
Anesthesia and Analgesia
|July 27, 2000
Summary
Major surgery like esophagectomy can impair heart function. This study found that elevated interleukin-6 (IL-6) levels after surgery are linked to reduced heart function, suggesting IL-6 may cause this dysfunction.
Area of Science:
- Cardiology
- Immunology
- Surgical Research
Background:
- Proinflammatory cytokines are linked to myocardial dysfunction after major surgery.
- Esophagectomy is a major surgical procedure that can impact cardiac function.
Purpose of the Study:
- To investigate the profile of proinflammatory cytokines after esophagectomy.
- To determine the association between cytokine levels and myocardial function post-esophagectomy.
Main Methods:
- Studied 12 patients undergoing subtotal esophagectomy.
- Measured serum levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) pre- and post-operatively.
- Assessed myocardial function using right ventricular ejection fraction (RVEF) and stroke volume index (SVI).
Main Results:
- IL-6 and IL-8 levels significantly increased postoperatively.
- RVEF and SVI significantly decreased at 6 and 12 hours postoperatively.
- Decreases in RVEF and SVI showed a strong negative correlation with IL-6 levels, but not IL-8.
Conclusions:
- Esophagectomy is associated with transient myocardial dysfunction.
- Elevated IL-6 levels may contribute to postoperative myocardial dysfunction following esophagectomy.