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Neoangiogenesis in the peritoneal membrane
R T Krediet1, M M Zweers, A C van der Wal
1Division of Nephrology, University of Amsterdam, The Netherlands.
Summary
Diabetiform neoangiogenesis, characterized by new blood vessel growth, is a key factor in ultrafiltration failure for patients undergoing long-term peritoneal dialysis. This condition mimics diabetic blood vessel changes and impacts peritoneal transport function.
Area of Science:
- Nephrology
- Vascular Biology
- Pathophysiology
Background:
- Long-term peritoneal dialysis (PD) can lead to changes in the peritoneal membrane.
- Understanding these changes is crucial for managing PD efficacy.
Purpose of the Study:
- To review publications on peritoneal vasculature.
- To establish morphological-functional relationships within the peritoneum.
Main Methods:
- Systematic review of relevant literature.
- Analysis of morphological and functional data from PD patients and animal models.
Main Results:
- Diabetiform neoangiogenesis observed in long-term PD patients.
- Similar abnormalities induced in rats with high glucose dialysis solution.
- Functional peritoneal transport abnormalities found in both rats and patients.
- Vascular endothelial growth factor implicated in glucose-induced neoangiogenesis.
Conclusions:
- Diabetiform peritoneal neoangiogenesis is a significant factor in ultrafiltration failure in long-term PD.
- This vascular change contributes to impaired peritoneal function over time.