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The parahippocampal cortices and kindling
1Department of Psychology, Carleton University, Ottawa, Ontario, Canada. dmcintyr@ccs.carleton.ca
Annals of the New York Academy of Sciences
|July 27, 2000
Summary
The piriform and perirhinal cortices play a key role in the generalization of limbic seizures, especially convulsive seizures. Lowered afterdischarge thresholds in these areas may underlie temporal lobe epilepsy.
Area of Science:
- Neuroscience
- Epileptology
Background:
- The piriform and perirhinal cortices are crucial parahippocampal structures.
- They exhibit strong connections with limbic areas like the amygdala and hippocampus, and other parahippocampal regions such as the entorhinal cortex.
Purpose of the Study:
- To investigate the role of the perirhinal and piriform cortices in the secondary generalization of limbic seizures.
- To explore the neural basis of temporal lobe epilepsy.
Main Methods:
- Anatomical studies
- Physiological studies
- Kindling studies
Main Results:
- Evidence suggests the perirhinal and piriform cortices are vital for secondary generalization of limbic seizures, particularly convulsive types.
- Kindling data indicate that reduced afterdischarge thresholds in parahippocampal structures contribute to temporal lobe epilepsy.
Conclusions:
- The piriform and perirhinal cortices are implicated in seizure generalization.
- Progressive lowering of afterdischarge thresholds in parahippocampal structures may be the neural basis for temporal lobe epilepsy.