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Validation of real-time continuous perfusion measurement.

G T Martin1, H F Bowman

  • 1Thermal Technologies, Inc. Cambridge, MA, USA. gmartin@thermaltechinc.com

Medical & Biological Engineering & Computing
|July 27, 2000
PubMed
Summary

A new thermal diffusion probe (TDP) accurately measures tissue perfusion in real-time. This minimally invasive technique offers a reliable method for continuous blood flow monitoring, crucial for various clinical applications.

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Area of Science:

  • Biomedical Engineering
  • Physiology
  • Medical Devices

Background:

  • Perfusion, or capillary blood replenishment, is vital for transporting heat, drugs, oxygen, and nutrients.
  • Existing perfusion measurement techniques often lack routine, continuous, and real-time capabilities.
  • Accurate, real-time perfusion assessment is critical for effective patient management in diverse clinical settings.

Purpose of the Study:

  • To validate a minimally invasive thermal diffusion probe (TDP) for absolute perfusion measurement.
  • To assess the TDP's ability to provide continuous, real-time perfusion data.
  • To compare TDP measurements with the established microsphere technique at low flow rates.

Main Methods:

  • A self-heated thermistor-based thermal diffusion probe (TDP) was employed for perfusion measurement.

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  • Simultaneous TDP and microsphere measurements were conducted in the liver of 27 rabbits.
  • Perfusion was measured across a range of 0 to 60 ml min-1 100 g-1.

    • Main Results:

    • The TDP demonstrated strong correlation with the microsphere technique (R2 = 0.898).
    • Excellent agreement was observed between TDP and microsphere measurements (slope ≈ 0.921, intercept ≈ 0.566).
    • Variability was attributed to microsphere sampling errors versus continuous TDP measurements.

    Conclusions:

    • The thermal diffusion probe (TDP) provides a validated, continuous, and real-time method for quantifying absolute perfusion.
    • This technology has significant potential to enhance patient management in fields like organ transplantation, neurosurgery, and oncology.
    • Real-time quantitative perfusion data can improve clinical decision-making and patient outcomes.