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Related Experiment Videos

Catch-up growth: possible mechanisms.

R I Gafni1, J Baron

  • 1Unit on Growth and Development, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1862, USA.

Pediatric Nephrology (Berlin, Germany)
|July 27, 2000
PubMed
Summary
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Systemic diseases can stunt growth, but catch-up growth after remission may restore stature. New research suggests growth plate mechanisms, not just the central nervous system, may drive this recovery.

Area of Science:

  • Pediatric endocrinology
  • Growth biology

Background:

  • Systemic diseases frequently impair linear growth in children.
  • Following disease remission, accelerated growth, termed catch-up growth, can occur, but final adult height is often suboptimal.

Purpose of the Study:

  • To review current models explaining catch-up growth.
  • To discuss emerging evidence suggesting local growth plate mechanisms.

Main Methods:

  • Literature review of existing models for catch-up growth.
  • Analysis of recent findings on localized growth plate responses.

Main Results:

  • The neuroendocrine model posits a central nervous system set-point for growth.
  • Evidence indicates localized catch-up growth within individual growth plates.

Related Experiment Videos

  • A novel model proposes growth plate stem cell proliferation is regulated locally.

    • Conclusions:

    • Catch-up growth mechanisms may involve both systemic and local factors.
    • Further research is required to elucidate the precise interplay of local and systemic regulation in catch-up growth.