Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of pentobarbital on visual processing in man.

E Martin1, T Thiel, P Joeri

  • 1Division of Magnetic Resonance, University Children's Hospital Zurich Steinwiesstrasse, Zürich, Switzerland. Ernst.Martin@kispi.unizh.ch

Human Brain Mapping
|July 27, 2000
PubMed
Summary

Sedative agents like pentobarbital significantly reduce brain activity signals during visual tasks. Higher doses caused negative blood-oxygen-level-dependent (BOLD) signals, impacting cerebral blood flow more than metabolism.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased cerebral infarct volumes in polyglobulic mice overexpressing erythropoietin.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2001
Same author

MRI analysis of the changes in apparent water diffusion coefficient, T(2) relaxation time, and cerebral blood flow and volume in the temporal evolution of cerebral infarction following permanent middle cerebral artery occlusion in rats.

Experimental neurology·2001
Same author

In-vivo cardiac studies in animals using magnetic resonance techniques: experimental aspects and MR readouts.

Magma (New York, N.Y.)·2001
Same author

Pulmonary edema induced by allergen challenge in the rat: noninvasive assessment by magnetic resonance imaging.

Magnetic resonance in medicine·2001
Same author

Visual processing in infants and children studied using functional MRI.

Pediatric research·1999
Same author

Ketamine attenuates endotoxin-induced leukocyte adherence in rat mesenteric venules.

Critical care medicine·1995

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Sedative agents are widely used in medical procedures.
  • Understanding their effects on brain function is crucial for patient safety.

Purpose of the Study:

  • To investigate the impact of sedative agents on human visual processing.
  • To analyze the dose-dependent effects of pentobarbital on brain activity.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to measure the blood-oxygen-level-dependent (BOLD) signal.
  • 15 healthy volunteers were tested under both alert and sedated states after pentobarbital administration.
  • A visual stimulation paradigm was employed to assess visual processing.

Main Results:

  • Pentobarbital significantly reduced BOLD signal strength in a dose-dependent manner.

Related Experiment Videos

  • Higher relative sedative dosages led to negative BOLD signals, indicating altered cerebral blood flow.
  • A reduction in positively correlating pixels was observed 15 minutes post-administration.

    • Conclusions:

    • Pentobarbital administration alters visual processing and reduces BOLD signal response.
    • The observed effects suggest pentobarbital has a greater impact on cerebral blood flow than cerebral oxidative metabolism.
    • Brain activity returned to baseline levels post-sedation.