Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Beyond a structural component: sphingolipids in immunology.

E E Prieschl1, T Baumruker

  • 1Department of Immunology, Novartis Research Institute, Vienna, Austria. eva.prieschl@pharma.novartis.com

Archivum Immunologiae Et Therapiae Experimentalis
|July 27, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)·2001
Same author

Selective inhibition of NF-AT DNA binding by the short-chain fatty acid n-butyrate.

Transplantation proceedings·2001
Same author

Sphingolipids: second messengers, mediators and raft constituents in signaling.

Immunology today·2000
Same author

Major histocompatibility complex class II- fetal skin dendritic cells are potent accessory cells of polyclonal T-cell responses.

Immunology·2000
Same author

The role of sphingosine kinase in the signaling initiated at the high-affinity receptor for IgE (FcepsilonRI) in mast cells.

International archives of allergy and immunology·2000
Same author

Glycosphingolipid-induced relocation of Lyn and Syk into detergent-resistant membranes results in mast cell activation.

Journal of immunology (Baltimore, Md. : 1950)·2000
Same journal

Heteronemin, a Scalarane Sesterterpenoid, Activates Apoptosis and Non-Apoptotic Ferroptosis and Inhibits Cytoprotective Autophagy in Oral Cancer Cells.

Archivum immunologiae et therapiae experimentalis·2026
Same journal

NCR1 and NCR3 Expression and Genetic Polymorphism are Associated with CMV Infection after Allogeneic Haematopoietic Stem Cell Transplantation.

Archivum immunologiae et therapiae experimentalis·2026
Same journal

USP25 Promotes Glycolysis of Acute Myeloid Leukemia Cells and Enhances Tumor Immunity.

Archivum immunologiae et therapiae experimentalis·2026
Same journal

sEV-Enriched Serum Preparations From Healthy Individuals Protect Against Acute Pancreatitis-Induced Intestinal Barrier Dysfunction Through miR-579-3p/ANXA3-Mediated Inhibition of NLRP3 Inflammasome Pyroptosis.

Archivum immunologiae et therapiae experimentalis·2026
Same journal

Herd-Trained Immunity: A Hidden Component of Population-Level Innate Immunity.

Archivum immunologiae et therapiae experimentalis·2026
Same journal

<i>Saccharomyces cerevisiae</i> β-Glucan Training Induces a Nonclassical PGE<sub>2</sub>-<sup>High</sup>/NO-<sup>Low</sup> Macrophage Phenotype in Response to <i>Pseudomonas aeruginosa</i> Exopolysaccharide.

Archivum immunologiae et therapiae experimentalis·2026
See all related articles

Sphingolipids, once thought only structural, are now known signaling molecules in immune cells. Their roles in cell death, signaling cascades, and diseases like cancer are key areas of research.

Area of Science:

  • Lipid signaling in immunology and cell biology.

Background:

  • Glycerol-based lipids (e.g., diacylglycerol) and sphingolipids (sphingosine, sphingosine-1-phosphate, ceramide) are key signaling molecules.
  • Sphingolipids, abundant in cell membranes, have functions beyond structure, including roles in apoptosis and signal transduction.
  • Sphingolipid-specific G-protein coupled receptors and their role as second messengers are increasingly understood.

Purpose of the Study:

  • To review novel insights into the signaling roles of sphingolipids.
  • To discuss the involvement of sphingolipids in disease pathology and therapeutic development.

Main Methods:

  • Literature review of recent findings on sphingolipid signaling.
  • Analysis of sphingolipid metabolism and its implications in diseases.
  • Overview of therapeutic strategies targeting sphingolipid pathways.

Related Experiment Videos

Main Results:

  • Sphingolipids act as crucial intracellular second messengers.
  • Glycosphingolipids in detergent-resistant membranes initiate signaling cascades.
  • Imbalances in sphingolipid metabolism contribute to disease pathogenesis.

Conclusions:

  • Sphingolipids are vital signaling molecules with diverse cellular functions.
  • Understanding sphingolipid metabolism offers new therapeutic avenues for diseases like cancer and inflammatory conditions.