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Association between the alpha-adducin gene and hypertension in the HyperGEN Study.

M A Province1, D K Arnett, S C Hunt

  • 1Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110, USA. mike@wubios.wustl.edu

American Journal of Hypertension
|July 27, 2000
PubMed
Summary
This summary is machine-generated.

The alpha-adducin gene Gly460Trp variant is a significant risk factor for hypertension in white individuals, but not in black individuals. Gene-environment interactions suggest it

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Area of Science:

  • Genetics and Genomics
  • Cardiovascular Disease Research
  • Human Physiology

Background:

  • Hypertension is a major global health concern with complex etiology.
  • Genetic factors play a role in hypertension development.
  • The alpha-adducin gene has been investigated as a potential contributor to hypertension risk.

Purpose of the Study:

  • To investigate the association between the alpha-adducin gene Gly460Trp polymorphism and hypertension in white and black subjects.
  • To identify potential gene-environment interactions influencing hypertension risk.
  • To determine if the alpha-adducin gene is an independent predictor of hypertension.

Main Methods:

  • Association study involving 822 white and 572 black subjects (cases and controls).
  • Genotyping for the alpha-adducin Gly460Trp point mutation.
  • Clinical examination for hypertension risk factors and multivariate logistic regression analysis.
  • Regression tree analysis to explore gene-environment interactions.

Main Results:

  • In whites, the Trp allele significantly increased hypertension odds (OR=1.73), remaining an independent predictor (OR=1.55).
  • Gene-environment interactions indicated alpha-adducin as a risk factor in older, less lean subjects with high triglycerides.
  • In blacks, the Trp allele showed a protective association overall (OR=0.48), but was not an independent predictor in multivariate analysis.

Conclusions:

  • The alpha-adducin gene Gly460Trp polymorphism is a significant, independent risk factor for hypertension in white populations.
  • The association of the alpha-adducin gene with hypertension differs between white and black individuals.
  • Specific gene-environment interactions highlight the complex role of alpha-adducin in hypertension pathogenesis.