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Relationship between hypertensive left ventricular hypertrophy and levels of endothelin and nitric oxide
1Cardiovascular Department of Internal Medicine, The Second Affiliated Hospital of Dalian Medical University, PR China.
Insights
Hypertensive left ventricular hypertrophy (LVH) is linked to higher endothelin (ET) and lower nitric oxide (NO) levels. These factors, ET and NO, independently influence hypertensive LVH development.
Area of Science:
- Cardiology
- Hypertension Research
- Vascular Biology
Background:
- Hypertensive left ventricular hypertrophy (LVH) is a significant complication of hypertension.
- Endothelin (ET) and nitric oxide (NO) play crucial roles in cardiovascular regulation.
- Understanding the interplay of ET and NO in hypertensive LVH is vital for developing targeted therapies.
Purpose of the Study:
- To investigate the relationship between hypertensive LVH and circulating levels of ET and NO.
- To establish an experimental foundation for preventing and treating hypertensive LVH.
- To determine the individual and combined roles of ET and NO in the pathogenesis of hypertensive LVH.
Main Methods:
- Echocardiography was used to assess left ventricular mass (LVM) and index (LVMI) in 58 hypertensive patients and 14 healthy controls.
- Hypertensive patients were categorized into LVH (+) and LVH (-) groups.
- Peripheral venous blood levels of ET and NO were measured, and regression analysis was performed.
Main Results:
- The LVH (+) group exhibited significantly higher ET levels and lower NO levels compared to the LVH (-) group.
- The ET/NO ratio was significantly elevated in hypertensive patients with LVH.
- Multiple regression analysis revealed that Mean Arterial Pressure (MAP), ET, and NO were independently correlated with LVMI, with ET showing a positive and NO a negative correlation.
Conclusions:
- Both ET and NO are implicated in the development of hypertensive LVH.
- The independent actions of ET and NO may explain the lack of correlation between the ET/NO ratio and hypertensive LVH.
- These findings highlight ET and NO as potential therapeutic targets for managing hypertensive LVH.
Abstract:
To investigate the relationship between hypertensive left ventricular hypertrophy (LVH) and levels of endothelin (ET) and nitric oxide (NO), and to provide an experimental basis for prevention and treatment of hypertensive LVH. Fifty eight hypertensive patients and 14 healthy controls were studied. All patients were examined by echocardiography. Left ventricular mass (LVM) and left ventricular mass index (LVMI) were calculated using Devereux RB formula. Hypertensive patients were divided into a LVH (+) group (n= 21) and a LVH (-) group (n=37), and the levels of endothelin and nitric oxide in the peripheral venous blood were measured. The mean ET level was significantly higher in the LVH (+) group than in LVH (-) group (p < 0.05), but the NO level was significantly lower in the LVH (+) group. The ET/NO ratio was significantly higher in the LVH (+) group than in LVH (-) group (p< 0.01). For the stepwise multiple regression analysis, the LVMI of hypertensive patients served as a dependent variable, and age, sex, BMI, MAP, ET, NO, and ET/NO served as independent variables. Only MAP, ET, and NO were found to have significant correlation to hypertensive LVH. ET had a significant positive correlation, and NO a significant negative relation to LVMI, but ET/NO showed no correlation to hypertensive LVH. ET and NO are involved in hypertensive LVH; the independent action of ET and NO in the pathogenesis of hypertensive LVH may weaken the relation between ET/NO and hypertensive LVH.