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Dual functions of Streptococcus salivarius urease
Y Y Chen1, C A Weaver, R A Burne
1Center for Oral Biology and Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA.
Journal of Bacteriology
|July 27, 2000
Abstract:
A urease-deficient derivative of Streptococcus salivarius 57.I was constructed by allelic exchange at the ureC locus. The wild-type strain was protected against acid killing through hydrolysis of physiologically relevant concentrations of urea, whereas the mutant was not. Also, S. salivarius could use urea as a source of nitrogen for growth exclusively through a urease-dependent pathway.