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Related Experiment Videos

Multicenter radial artery patency study (RAPS). Study design.

S E Fremes1

  • 1Sunnybrook and Women's College Health Science Centre, Toronto, Ontario, Canada.

Controlled Clinical Trials
|July 29, 2000
PubMed
Summary
This summary is machine-generated.

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The radial artery shows comparable patency to saphenous vein grafts for coronary artery bypass surgery in non-left anterior descending targets. This finding supports the expanded use of arterial conduits in cardiac procedures.

Area of Science:

  • Cardiovascular Surgery
  • Vascular Grafting
  • Interventional Cardiology

Background:

  • Internal thoracic artery grafts improve long-term outcomes for left anterior descending coronary artery bypass.
  • Expanded use of arterial conduits for other coronary targets is advocated.
  • The radial artery has advantageous anatomic features for use as a bypass graft.

Purpose of the Study:

  • To determine the relative graft patency of the radial artery compared to the saphenous vein for right and circumflex coronary artery bypass.
  • To evaluate the efficacy of radial artery grafts in patients with multivessel coronary disease.

Main Methods:

  • A randomized controlled trial comparing radial artery and saphenous vein grafts in the same patients (serving as their own controls).
  • Patients with multivessel coronary disease and ejection fraction >/= 35% were eligible.

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  • Graft patency was assessed by angiography 8-12 months postoperatively.

    • Main Results:

    • The study aims to recruit 560 patients to achieve 80% power for detecting a 40% relative reduction in distal anastomotic occlusion.
    • Interim analysis of 128 patients with follow-up angiography shows promising results, with approximately 80% of those followed for over a year undergoing angiography.
    • The trial is designed to control for patient and vessel factors through its within-patient comparison design.

    Conclusions:

    • This trial will provide crucial data on the 8-12 month patency of radial artery versus saphenous vein grafts for non-left anterior descending coronary bypass.
    • Positive results would support the increased utilization of the radial artery and arterial grafts in general for coronary artery bypass surgery.