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Related Experiment Videos

Candida glabrata displays pseudohyphal growth.

C Csank1, K Haynes

  • 1Eukaryotic Genetics Group, National Research Council of Canada, Biotechnology Research Institute, Montreal, Quebec.

FEMS Microbiology Letters
|July 29, 2000
PubMed
Summary

Candida glabrata can switch to a filamentous form, forming invasive pseudohyphae on specific media. This morphological change is crucial for understanding fungal pathogenesis and invasive growth.

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Area of Science:

  • Microbiology
  • Mycology
  • Cell Biology

Background:

  • Morphological plasticity is a key factor in fungal pathogenesis.
  • Previous studies have not extensively documented morphological changes in Candida glabrata.

Purpose of the Study:

  • To investigate the morphological changes of Candida glabrata under different growth conditions.
  • To determine if Candida glabrata exhibits invasive filamentous growth.

Main Methods:

  • Culturing Candida glabrata ATCC2001 on solid nitrogen starvation media (SLAD).
  • Supplementing SLAD with ammonium sulfate to observe effects on growth.
  • Comparing growth patterns with diploid Saccharomyces cerevisiae strains on YPD media.

Main Results:

  • Candida glabrata formed elongated pseudohyphal chains on SLAD, invading the agar.
  • Pseudohyphal growth was inhibited by ammonium sulfate in both C. glabrata and S. cerevisiae.
  • C. glabrata exhibited invasive agar invasion on SLAD, distinct from its non-invasive growth on YPD.

Conclusions:

  • This study provides the first evidence of morphological change and invasive filamentous growth in Candida glabrata.
  • The ability to form pseudohyphae and invade is condition-dependent.
  • Understanding these morphological changes is vital for fungal pathogenesis research.

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