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Nutritional assessment of peripheral blood stem cell transplantation in children
T Kajiume1, S Yoshimi, K Kobayashi
1Satou Memorial Hospital, Okayama, Japan. kajiume@d4.dion.ne.jp
Insights
Peripheral blood stem cell transplantation (PBSCT) offers rapid recovery, with nutritional markers returning to normal within 28 days. This study suggests PBSCT has minimal impact on pediatric patients
Area of Science:
- Hematology
- Pediatric Oncology
- Nutritional Science
Background:
- Peripheral blood stem cell transplantation (PBSCT) is favored over bone marrow transplantation due to faster recovery of hematopoiesis and general condition.
- The impact of PBSCT on nutritional status, particularly in pediatric patients, requires further investigation.
Purpose of the Study:
- To investigate the duration of nutritional insufficiency in children undergoing PBSCT.
- To evaluate the recovery of key nutritional parameters post-PBSCT in pediatric patients with malignant diseases.
Main Methods:
- Study included 8 pediatric patients with malignant diseases undergoing PBSCT.
- Measured parameters included body weight, body fat, cholesterol, albumin, pre-albumin, and retinol-binding protein.
- Measurements were taken weekly for 4 weeks post-transplantation, starting one day prior.
Main Results:
- All measured nutritional parameters reached their lowest point during transplantation and subsequently recovered by day 28.
- Parameters such as body weight, body fat, cholesterol, albumin, pre-albumin, and retinol-binding protein showed a comparatively early return to normal levels.
- The study indicates that PBSCT causes minimal nutritional damage in pediatric patients.
Conclusions:
- Pediatric patients undergoing PBSCT experience a rapid nutritional recovery within 28 days post-transplantation.
- PBSCT is associated with limited negative effects on nutritional status in children with malignant diseases.
- The findings support the hypothesis that PBSCT leads to quicker nutritional rehabilitation compared to traditional bone marrow transplantation.
Abstract:
Peripheral blood stem cell transplantation (PBSCT) has many advantages for patients because hematopoiesis and general condition return to normal more rapidly than they do following bone marrow transplantation. Thus, the authors hypothesize that the nutritional condition of patients also returns to normal more rapidly after PBSCT. The duration of insufficient nutrition was investigated in children undergoing PBSCT. The subjects of this study were 8 patients with malignant diseases. The factors measured were body weight, body fat, cholesterol, albumin, pre-albumin, and retinol-binding protein. These parameters were measured a day before transplantation, and then once a week for 4 weeks after transplantation. All parameters were recovered until day 28 from the lowest level in transplantation. In this study, all parameters returned to normal comparatively early. PBSCT causes little damage to patients' nutrition.