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Related Experiment Video

Updated: Jul 22, 2026

Isolation of Sertoli Cells and Peritubular Cells from Rat Testes

Isolation of Sertoli Cells and Peritubular Cells from Rat Testes

Published on: February 8, 2016

Unique cellular features in a testicular plasmacytoma.

W D Meek¹, S E Rose, S S Sands

¹Department of Anatomy and Cell Biology, Oklahoma State University College of Osteopathic Medicine, Tulsa, USA. meekwd@osu-com.okstate.edu

Ultrastructural Pathology

|July 29, 2000

Summary

This study details a rare testicular plasmacytoma in a multiple myeloma patient, noting unique cytoplasmic and intranuclear inclusions. These findings offer new insights into advanced plasma cell disorders.

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Area of Science:

Oncology
Pathology
Cell Biology

Background:

Multiple myeloma is a plasma cell malignancy.
Testicular involvement in multiple myeloma is uncommon.
Plasmacytomas represent localized plasma cell tumors.

Observation:

A case study of a 54-year-old male with a history of multiple myeloma.
The testicular tumor exhibited interstitial space growth.
Plasma cells showed varied differentiation, including features of connective tissue plasma cells.

Findings:

Characteristic cytoplasmic inclusions were observed in most plasma cells.
A significant number of intranuclear inclusions were identified.
This is the first report of such inclusions in testicular plasmacytoma cells.

Implications:

The presence and significance of these inclusions in end-stage myeloma require further investigation.
Understanding these cellular anomalies may enhance diagnostic criteria for plasma cell neoplasms.
This case contributes to the understanding of extraskeletal manifestations of multiple myeloma.