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Effect of 3 dentifrices containing triclosan and various additives. An experimental gingivitis study
G R Nogueira-Filho1, S Toledo, J A Cury
1Department of Periodontics, Faculty of Dentistry, Piracicaba-UNICAMP, Piracicaba, SP, Brazil.
Background:
The antiplaque and antigingivitis effect of 3 dentifrices was evaluated using the 21-day partial-mouth experimental model of gingivitis.
Method:
25 volunteers took part in this cross-over, double-blind study, carried out in 4 phases of 21 days each. For each phase of the study, a toothshield of the IV quadrant was constructed for each volunteer. 2 antiplaque dentifrices from the market, one containing triclosan + pvm/ma and the other triclosan + Zn, were compared with an experimental formulation and its placebo. The experimental dentifrice contained triclosan + pvm/ma + Zn + PPi and the placebo (control) did not contain these substances. The subjects were stratified according to their whole-mouth baseline plaque (PI), gingivitis (GI) and bleeding (BI) index scores, and then randomly assigned to 1 of 4 dentifrices. During each phase, while the volunteers brushed their teeth with one of the dentifrices, the IV quadrant was protected by the toothshield filled with the dentifrice used. After each phase, dental plaque, gingivitis and bleeding indices were determined.
Results:
The results showed that only the formulation containing triclosan + pvm/ma + Zn + PPi was able to reduce PI (28.8%), GI (35.9%) and BI (30.4%) in comparison with controls (p<0.05).
Conclusions:
The data suggest that a dentifrice containing the combination of triclosan + pvm/ma + Zn + PPi should be formulated for dental plaque control.