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Detection of Functional Matrix Metalloproteinases by Zymography
Published on: November 8, 2010
Difluoroketones as inhibitors of matrix metalloprotease-13
L A Reiter1, G J Martinelli, L A Reeves
1Pfizer Inc., Central Research Division, Groton, CT 06340, USA. lawrence_a_reiter@groton.pfizer.com
Bioorganic & Medicinal Chemistry Letters
|July 29, 2000
Abstract:
Substrate-like difluoroketones have been prepared as potential inhibitors of MMP-13. Weak inhibition was seen with the key target 2. This and the more potent activity of intermediate 7b illustrates that hydrated ketones can be used to inhibit MMP-13 and perhaps other members of this class of enzymes.
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01:30Enzyme Inhibition
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01:23Role of Matrix Metalloproteases in Degradation of ECM
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