Topical ketanserin gel for anal fissure: an open-label, prospective study

This open-label, prospective study assessed the efficacy and safety of topical ketanserin gel in 63 patients with symptomatic anal fissure. The efficacy outcome was total clinical healing of the fissure. Topical ketanserin gel was 90% effective (fissure healed) and 100% safe (no adverse events) in the primary nonsurgical treatment of anal fissure.