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Delayed graft function influences renal function, but not survival.

H Boom1, M J Mallat, J W de Fijter

  • 1Departments of Nephrology and Medical Statistics, Leiden University Medical Center, The Netherlands. hboom@nephrology.azl.nl

Kidney International
|August 1, 2000
PubMed
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Delayed graft function (DGF) in kidney transplants is linked to suboptimal function and acute rejection, but not graft loss. Avoidable risk factors include low blood pressure, female donor to male recipient, and long cold ischemia times.

Area of Science:

  • Nephrology
  • Transplantation immunology
  • Clinical research

Background:

  • The impact of delayed graft function (DGF) on renal transplant outcomes remains debated.
  • Identifying risk factors and consequences of DGF is crucial for improving graft survival.

Purpose of the Study:

  • To analyze the risk factors associated with DGF in cadaveric renal transplantation.
  • To evaluate the impact of DGF on early and long-term graft function and survival.

Main Methods:

  • Retrospective analysis of 734 cadaveric renal transplants (1983-1997).
  • DGF defined by creatinine levels in the first week post-transplant.
  • Logistic and Cox regression models used to identify risk factors and survival influences.

Related Experiment Videos

Main Results:

  • Key DGF risk factors identified: low recipient mean arterial blood pressure, female donor to male recipient, older donor age, prolonged cold ischemia time, and high panel reactive antibodies.
  • DGF independently predicted suboptimal graft function at one year and acute rejection episodes.
  • DGF did not independently impact long-term graft survival.

Conclusions:

  • Potentially modifiable risk factors for DGF include recipient blood pressure, donor-recipient sex match, and cold ischemia time.
  • While DGF contributes to acute rejection and poorer early function, it does not independently reduce long-term graft survival.