Specificity of brain-reactive antibodies in serum of old mice

Previous studies in our laboratory demonstrated that brain-reactive antibodies are present in the serum of old mice and these are separated from the brain antigen by the blood-brain barrier. In this paper the specificity of these antibodies to neuronal antigen has been studied using sera from old mice with or without absorption by the homogenates of different organs and also by direct treatment with sections of those organs. The results indicate that these brain-reactive antibodies found in sera of old mice are specific to neuronal antigen in the central nervous system.