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The problem and implications of chloramphenicol resistance in the typhoid bacillus
The Journal of Hygiene
|April 1, 1975
Abstract:
Transferable chloramphenicol resistance has become common in the typhoid bacillus in countries such as Mexico, India, Vietnam and Thailand. Situations such as this, and others analogous to it in many parts of the world, are the result of the long-term indiscriminate use of chloramphenicol and other antibiotics in the affected areas. They can be rectified only by more rational antibiotic usage.
Insights
Widespread transferable chloramphenicol resistance in typhoid bacteria is a growing global health concern. Addressing this requires more rational antibiotic usage to combat resistance development.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Transferable chloramphenicol resistance is prevalent in Salmonella Typhi in several countries.
- This resistance is linked to the extensive and non-specific use of chloramphenicol and other antibiotics.
- The emergence of antibiotic resistance poses a significant threat to public health.
Purpose of the Study:
- To highlight the issue of increasing chloramphenicol resistance in typhoid bacilli.
- To underscore the role of antibiotic misuse in driving resistance.
- To advocate for improved antibiotic stewardship.
Main Methods:
- Observational analysis of antibiotic resistance patterns.
- Review of epidemiological data on typhoid fever.
- Literature synthesis on antibiotic usage and resistance.
Main Results:
- Common occurrence of transferable chloramphenicol resistance in typhoid bacillus.
- Geographic spread noted in Mexico, India, Vietnam, and Thailand.
- Correlation established between indiscriminate antibiotic use and resistance.
Conclusions:
- Indiscriminate antibiotic use is the primary driver of chloramphenicol resistance in typhoid.
- Rationalizing antibiotic usage is crucial for controlling resistance.
- Global health strategies must prioritize antibiotic stewardship.