Related Experiment Video
Updated: Jun 29, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 11, 2013
Respiratory syncytial virus-induced chronic bronchiolitis in experimentally infected calves
S Philippou1, P Otto, P Reinhold
1Institute of Pathology, Augusta Hospital, Bochum, Germany.
Abstract:
Human (RSV) and bovine (BRSV) respiratory syncytial virus cause similar infections of the lower respiratory tract. Therefore, experimentally infected calves are suited to the study of RSV-induced chronic bronchiolitis. Colostrum-fed calves aged 17-24 days were successfully infected with BRSV. BRSV strain 375 was applied as an aerosol on 4 consecutive days. Clinical symptoms were already evident on the 1st day after infection. The calves were necropsied 12 weeks after the first infection. Focal severe chronic bronchiolitis with atelectasis and focal bronchiolitis obliterans were demonstrated. The bronchiolar lumina were filled with secretion. Transmission electron microscopy revealed an alteration of the ciliogenesis and partial loss of cilia. Immunhistochemically virus P protein could still be detected, mainly in the epithelial cells of the inflamed bronchioli.
Related Concept Videos
Pulmonary Cycle: Exhalation
Pneumonia II: Pathophysiology
Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Respiratory Syncytial Virus Disease
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

