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Related Experiment Videos

Treatment for posttraumatic stress disorder.

M Cyr1, M K Farrar

  • 1Veterans Affairs Medical Center, Memphis, TN, USA. mcyr@utmem.edu

The Annals of Pharmacotherapy
|August 5, 2000
PubMed
Summary

Current research on posttraumatic stress disorder (PTSD) pharmacologic treatment is limited. While monoamine oxidase inhibitors show promise, more rigorous studies are needed to establish definitive PTSD treatment guidelines.

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Psychology

Background:

  • Posttraumatic stress disorder (PTSD) is a complex mental health condition.
  • Understanding PTSD symptomatology, diagnosis, epidemiology, pathophysiology, and assessment is crucial for effective treatment.
  • Pharmacologic interventions are a key component of PTSD management.

Purpose of the Study:

  • To critically review the current pharmacologic treatment options for PTSD.
  • To synthesize existing knowledge on PTSD's various facets, including symptoms, diagnosis, and pathophysiology.
  • To identify gaps in the literature regarding PTSD pharmacotherapy.

Main Methods:

  • A comprehensive MEDLINE search (1966-October 1999) focused on PTSD drug treatment.
  • Prioritization of randomized, double-blind, placebo-controlled studies for data extraction.
  • Review of identified articles for efficacy and safety of pharmacologic agents.

Main Results:

  • A minimum five-week medication trial is suggested for assessing PTSD symptom response.
  • Monoamine oxidase inhibitors appear more effective than tricyclic antidepressants for reexperiencing and avoidance symptoms.
  • Limited data exists on hyperarousal symptom treatment due to inadequate assessment tools in most studies.

Conclusions:

  • The current evidence base lacks sufficient high-quality studies to establish definitive PTSD pharmacologic treatment guidelines.
  • Antidepressants, particularly monoamine oxidase inhibitors and tricyclic antidepressants, form the basis for a potential treatment hierarchy.
  • Other agents like mood stabilizers, antipsychotics, anxiolytics, and adrenergic blockers are not primary PTSD treatments.

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