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Opioid growth factor modulates angiogenesis.

J Blebea1, J E Mazo, T K Kihara

  • 1Department of Surgery and the Department of Neuroscience and Anatomy, The Pennsylvania State University College of Medicine, Hershey, PA, USA.

Journal of Vascular Surgery
|August 5, 2000
PubMed
Summary
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Endogenous opioids, specifically opioid growth factor (OGF), inhibit angiogenesis in vivo. Blocking OGF with naltrexone promotes blood vessel growth, suggesting a therapeutic target for vascular diseases.

Area of Science:

  • Molecular Biology
  • Vascular Biology
  • Endocrinology

Background:

  • Induced angiogenesis is a therapeutic strategy for occlusive arterial atherosclerotic disease.
  • The role of endogenous opioids in modulating angiogenesis remains largely unexplored.

Purpose of the Study:

  • To investigate the potential role of endogenous opioids in regulating angiogenesis.
  • To determine if opioid growth factor (OGF) influences blood vessel formation in vivo.

Main Methods:

  • Utilized the chick chorioallantoic membrane (CAM) as an in vivo model for angiogenesis.
  • Applied OGF, opioid receptor antagonists (naloxone, naltrexone), retinoic acid, and vascular endothelial growth factor (VEGF) to CAMs.
  • Quantified blood vessel number and length using digital imaging and performed immunocytochemistry for OGF and its receptor (OGFr).

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Main Results:

  • Opioid growth factor significantly inhibited angiogenesis, reducing blood vessel number and length by 35% and 20%, respectively.
  • Naltrexone, an opioid antagonist, significantly increased blood vessel number and length by 51% and 24%, indicating receptor-mediated effects.
  • OGF and OGFr were detected in endothelial and mesenchymal cells of the CAM vasculature.

Conclusions:

  • Endogenous opioids, particularly OGF, play a significant role in modulating in vivo angiogenesis.
  • OGF acts as a tonically active peptide regulating angiogenesis through receptor-mediated mechanisms.
  • These findings highlight a novel pathway for therapeutic intervention in vascular diseases.