Accommodating haploinsufficient tumor suppressor genes in Knudson's model

RIPK1- and RIPK3-induced cell death mode is determined by target availability.

Cell death and differentiation·2014

Necroptosis induced by RIPK3 requires MLKL but not Drp1.

Cell death & disease·2014

TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1.

Cell death & disease·2013

In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-κB, but caspase-8 is required for TNF to cause cell death, and induction of FLIP by NF-κB is required to prevent it.

Cell death and differentiation·2011

Identification and characterization of mErk5-T, a novel Erk5/Bmk1 splice variant.

Gene·2005

A simple method for the measurement of polymerization shrinkage in dental composites.

Dental materials : official publication of the Academy of Dental Materials·2000

Tumor microenvironment-simulated organoids for personalized therapy prediction in head and neck squamous cell carcinoma.

Oncogene·2026

CHAF1A promotes RAD51 loading and homologous recombination to drive tumor radioresistance.

Oncogene·2026

Metabolic CRISPR screening identifies RPE as a key regulator of acquired enzalutamide resistance through FKBP5 destabilization in prostate cancer.

Oncogene·2026

UNC5B regulates epithelial-to-mesenchymal transition through a SRC-ZEB1 signaling axis to facilitate pancreatic cancer metastasis.

Oncogene·2026

PROTAC-mediated targeting of IKKβ and NR4A1 for AML therapy.

Oncogene·2026

LncRMRP drives bladder cancer invasion via a lactylation-driven positive feedback circuit.

Oncogene·2026

A Novel tsRNA, 5'tiRNA-GluCTC, Mediates Cardiomyocyte-Fibroblast Crosstalk to Promote Cardiac Fibrosis in Restrictive Cardiomyopathy.

Clinical science (London, England : 1979)·2026

A Metabo-Reprogramming Niche Remodeling System Halts Osteoarthritis by Restoring the FGF21-Arginine Axis.

Advanced materials (Deerfield Beach, Fla.)·2026

Spatiotemporally Controlled Lysosomal Membrane Permeabilization Amplifies STING-Driven Antitumor Immunity in Prostate Cancer.

Advanced materials (Deerfield Beach, Fla.)·2026

Programmed Cell Death: A Key Mechanism of Traditional Chinese Medicine in the Treatment of Membranous Nephropathy.

Drug design, development and therapy·2026

Ten-Year Disease Control of Metastatic Pancreatic Neuroendocrine Tumour Treated With Everolimus.

Cureus·2026

HO-1 Up-regulation and PINK1/Parkin-Mediated Mitophagy Contribute to the Anti-tumor Effects of Metochalcone in Colorectal Cancer.

Research (Washington, D.C.)·2026

Related Experiment Videos

Accommodating haploinsufficient tumor suppressor genes in Knudson's model

Related Concept Videos

RIPK1- and RIPK3-induced cell death mode is determined by target availability.

Necroptosis induced by RIPK3 requires MLKL but not Drp1.

TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1.

In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-κB, but caspase-8 is required for TNF to cause cell death, and induction of FLIP by NF-κB is required to prevent it.

Identification and characterization of mErk5-T, a novel Erk5/Bmk1 splice variant.

A simple method for the measurement of polymerization shrinkage in dental composites.

Tumor microenvironment-simulated organoids for personalized therapy prediction in head and neck squamous cell carcinoma.

CHAF1A promotes RAD51 loading and homologous recombination to drive tumor radioresistance.

Metabolic CRISPR screening identifies RPE as a key regulator of acquired enzalutamide resistance through FKBP5 destabilization in prostate cancer.

UNC5B regulates epithelial-to-mesenchymal transition through a SRC-ZEB1 signaling axis to facilitate pancreatic cancer metastasis.

PROTAC-mediated targeting of IKKβ and NR4A1 for AML therapy.

LncRMRP drives bladder cancer invasion via a lactylation-driven positive feedback circuit.

A Novel tsRNA, 5'tiRNA-GluCTC, Mediates Cardiomyocyte-Fibroblast Crosstalk to Promote Cardiac Fibrosis in Restrictive Cardiomyopathy.

A Metabo-Reprogramming Niche Remodeling System Halts Osteoarthritis by Restoring the FGF21-Arginine Axis.

Spatiotemporally Controlled Lysosomal Membrane Permeabilization Amplifies STING-Driven Antitumor Immunity in Prostate Cancer.

Programmed Cell Death: A Key Mechanism of Traditional Chinese Medicine in the Treatment of Membranous Nephropathy.

Ten-Year Disease Control of Metastatic Pancreatic Neuroendocrine Tumour Treated With Everolimus.

HO-1 Up-regulation and PINK1/Parkin-Mediated Mitophagy Contribute to the Anti-tumor Effects of Metochalcone in Colorectal Cancer.

Related Experiment Videos

Accommodating haploinsufficient tumor suppressor genes in Knudson's model

Related Concept Videos

Related Articles